Overview
Orthocell’s autologous tendon therapy is the most advanced injectable cellular therapy for the treatment of chronic tendon injuries. The patient’s own healthy tendon derived cells are used to assist in the regeneration of damaged tendon to reduce pain and return function. The innovative therapy addresses a significant unmet clinical need for a safe, effective, and non-surgical solution.
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How it works
Autologous tendon therapy is a two-stage procedure. A biopsy of healthy tendon, typically from the patella tendon, is performed in a doctor’s rooms using local anaesthetic. The biopsied tissue is sent to Orthocell’s quality-controlled laboratory where the cellular building blocks of the tendon, the tenocytes, are isolated and grown to a clinically significant number under controlled conditions. Finally, the tendon cells are then implanted by injection into the affected tendon approximately 4 – 5 weeks after the initial biopsy via ultrasound-guided injection under local anaesthetic.
Publications
- Bucher TA et al. Autologous tenocyte injection for the treatment of chronic recalcitrant gluteal tendinopathy - A prospective pilot study. Orthop j Sports Med.
2017 Feb - Bhabra G et al. Lateral elbow tendinopathy: development of a pathophysiology-based treatment algorithm. Orthop J Sports Med.
2016 Nov - Raina D et al. A biphasic bone substitute with gentamycin regenerates bone in osteomyelitis with muscle acting as an osteoinductive niche. Orthopaedic Proceedings.
2015 Oct - Wang A et al. Evidence for the durability of autologous tenocyte injection for treatment of chronic resistant lateral epicondylitis - Mean 4.5 year clinical follow-up. AM J Sports Med
2015 Jul - Wang A et al. Autologous tenocyte injection for the treatment of severe, chronic resistant lateral epicondylitis: a pilot study. Am J Sports Med.
2013 Dec - Wang A elt al. Autologous tenocyte implantation, a novel treatment for partial-thickness rotator cuff tear and tendinopathy in an elite athlete. BMJ Case Rep.
2013 Jan - Chen J et al. Autologous Tenocyte therapy for experimental achilles tendinopathy in a rabbit model. Tissue Eng Part A.
2011 Aug - Chen J et al. In chronic lateral epicondylitis, apoptosis and autophagic cell death occur in the extensor carpi radialis brevis tendon. J Shoulder Elbow Surg.
2010 Apr - Chen J et al. Autologous tenocyte therapy using porcine derived bio-scaffolds for massive rotator cuff defects in rabbits. Tissue Eng.
2007 Jul
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