CelGro™ Platform Collagen Medical Device
CelGro™ platform of collagen medical devices are designed to augment surgical repair of bone and soft tissue. CelGro™ is manufactured using a proprietary SMRT™ manufacturing process to preserve the natural collagen structure. The devices are completely absorbed by the body and can be used alone or combined with cell therapies to augment the repair of bone, nerve, tendon and cartilage defects.
|The membrane prevents infiltration of cells and enables the passage of bioactive molecules and proteins||Porous network of collagen fibers promotes cellular attachment and proliferation||Bioactive chamber supports new tissue formation and integration of the membrane at the repair site|
How it works
CelGro™’s natural bilayer structure, which features smooth and rough sides, acts to both guide new tissue formation and protect the repair site.
Smooth layer – a parallel arrangement of densely packed collagen bundles with abundant pores permits the passage of fluids and nutrient molecules while preventing the invasion of external tissue into the site of repair.
Rough layer – consists of loosely arranged collagen bundles to provide a scaffold to support new cell growth.
Tissue remodeling – cells from the regenerating tissue integrate with the collagen fibres to guide tissue regeneration.
Cell therapy aims to treat diseased or damaged tissue by local implantation or injection of healthy cells where tissue repair is needed. The use of a patient’s own cells (autologous) to repair tissue damage reduces the risk of rejection or transmission of infectious diseases.
Innovative treatment for chronic tendon injuries
Orthocell’s autologous tendon therapy is the most advanced injectable cellular therapy for the treatment of chronic tendon injuries. The patient’s own healthy tendon derived cells are used to assist in the regeneration of damaged tendon to reduce pain and return function. The innovative therapy addresses a significant unmet clinical need for a safe, effective, and non-surgical solution. Orthocell is at the clinical stage of development for this innovative cell therapy with more than 1,000 patients treated.
Regeneration of human cartilage
OrthoACI™ (Autologous Chondrocyte Implantation) offers treatment for symptomatic cartilage defects of the knee and ankle. Damaged cartilage has a limited capacity for self-repair and if left untreated, the cartilage damage may progress to the point where joint replacement is required. OrthoACI™ uses the patient’s own healthy cartilage cells, called chondrocytes, to assist in the regeneration of cartilage tissue. OrthoACI™ is available for use in Australia.